Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 15 January 2008
Vol. 1, Issue 2, p. ec19
[DOI: 10.1126/stke.12ec19]

EDITORS' CHOICE

Molecular Biology Expressing Estrogen-Responsive Genes

Beverly A. Purnell

Science, AAAS, Washington, DC 20005, USA

Estrogens, upon recruitment of their cognate receptors, govern the expression of target genes. Perillo et al. show that transcription of estrogen-responsive genes is driven by hormone-dependent demethylation of a critical lysine in histone H3 to induce a local oxidative burst that modifies the surrounding DNA by guanine oxidation, which is subsequently removed by specific glycosylases. 8-oxo-guanine-DNA glycosylase 1 and the topoisomerase IIβ enzyme are recruited to these loci and bend the intervening DNA-chromatin region to mark the site where transcription begins and drive expression of estrogen-responsive genes.

B. Perillo, M. N. Ombra, A. Bertoni, C. Cuozzo, S. Sacchetti, A. Sasso, L. Chiariotti, A. Malorni, C. Abbondanza, E. V. Avvedimento, DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science 319, 202-206 (2008). [Abstract] [Full Text]

Citation: B. A. Purnell, Expressing Estrogen-Responsive Genes. Sci. Signal. 1, ec19 (2008).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882