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Sci. Signal., 15 January 2008
Vol. 1, Issue 2, p. ec20
[DOI: 10.1126/stke.12ec20]


Cell Biology Where the PS Is

Stella M. Hurtley

Science, AAAS, Cambridge CB2 1LQ, UK

The surface charge of the plasma membrane is a crucial determinant of the targeting of signaling proteins. Yeung et al. have developed a probe that can reveal the location of the major negatively charged phospholipid, phosphatidylserine (PS), within cell membranes. PS was found in the cytosolic leaflet of the plasma membrane and on endosomes and lysosomes. It appeared to play a role in the targeting of a variety of positively charged proteins within these membranes.

T. Yeung, G. E. Gilbert, J. Shi, J. Silvius, A. Kapus, S. Grinstein, Membrane phosphatidylserine regulates surface charge and protein localization. Science 319, 210-213 (2008). [Abstract] [Full Text]

Citation: S. M. Hurtley, Where the PS Is. Sci. Signal. 1, ec20 (2008).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882