Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 15 January 2008
Vol. 1, Issue 2, p. ec21
[DOI: 10.1126/stke.12ec21]

EDITORS' CHOICE

Medicine EPCs at the Switch

Paula A. Kiberstis

Science, AAAS, Washington, DC 20005, USA

To ensure a steady supply of oxygen and nutrients, tumors send signals that stimulate the growth of new blood vessels. Bone marrow-derived cells called endothelial progenitor cells (EPCs) are known to be recruited to the tumor-associated growing vessels, but the presence of these cells at only very low levels in the tumor vasculature has made it difficult to assess their functional contribution. Studying mouse models of lung metastasis, Gao et al. (see the Perspective by Rafii and Lyden) show that EPCs are critical regulators of the "angiogenic switch" that helps drive the progression of dormant micrometastases to lethal metastases. Genetic manipulations that blocked EPC mobilization in tumor-bearing mice inhibited angiogenesis, impaired formation of lung metastases, and increased survival time.

D. Gao, D. J. Nolan, A. S. Mellick, K. Bambino, K. McDonnell, V. Mittal, Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 319, 195-198 (2008). [Abstract] [Full Text]

S. Rafii, D. Lyden, A few to flip the angiogenic switch. Science 319, 163-164 (2008). [Summary] [Full Text]

Citation: P. A. Kiberstis, EPCs at the Switch. Sci. Signal. 1, ec21 (2008).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882