Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 27 May 2008
Vol. 1, Issue 21, p. pe23
[DOI: 10.1126/stke.121pe23]

PERSPECTIVES

Diversification of the Function of Cell-to-Cell Signaling in Regulation of Virulence Within Plant Pathogenic Xanthomonads

Max Dow*

BIOMERIT Research Centre, Department of Microbiology, BioSciences Institute, National University of Ireland, Cork, Ireland.

Abstract: The virulence of plant pathogenic bacteria belonging to the genera Xanthomonas and Xylella depends upon cell-to-cell signaling mediated by the diffusible signal molecule DSF (Diffusible Signaling Factor). Synthesis and perception of the DSF signal require products of the rpf gene cluster. The synthesis of DSF depends on RpfF, whereas the RpfC/RpfG two-component system is implicated in DSF perception and signal transduction. The sensor RpfC acts to negatively regulate synthesis of DSF. In Xanthomonas campestris, mutation of rpfF or rpfC leads to a coordinate down-regulation in synthesis of virulence factors and a reduction in virulence. In contrast, in Xylella fastidiosa, the causal agent of Pierce’s disease of grape, mutation of rpfF and rpfC have opposite effects on virulence, with rpfF mutants exhibiting a hypervirulent phenotype. The findings suggest that different xanthomonads have adapted the perception and function of similar types of signaling molecule to fit the specific needs for colonization of different hosts.

*Corresponding author. E-mail: m.dow{at}ucc.ie

Citation: M. Dow, Diversification of the Function of Cell-to-Cell Signaling in Regulation of Virulence Within Plant Pathogenic Xanthomonads. Sci. Signal. 1, pe23 (2008).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The RpfCG two-component system negatively regulates the colonization of sugar cane stalks by Xanthomonas albilineans.
P. Rott, L. A. Fleites, I. Mensi, L. Sheppard, J.-H. Daugrois, J. M. Dow, and D. W. Gabriel (2013)
Microbiology 159, 1149-1159
   Abstract »    Full Text »    PDF »
The xrvA gene of Xanthomonas oryzae pv. oryzae, encoding an H-NS-like protein, regulates virulence in rice.
J.-X. Feng, Z.-Z. Song, C.-J. Duan, S. Zhao, Y.-Q. Wu, C. Wang, J. M. Dow, and J.-L. Tang (2009)
Microbiology 155, 3033-3044
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882