Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 27 May 2008
Vol. 1, Issue 21, p. pe25
[DOI: 10.1126/stke.121pe25]

PERSPECTIVES

ETosis: A Novel Cell Death Pathway

Florian Wartha and Birgitta Henriques-Normark*

Department of Bacteriology, Swedish Institute for Infectious Disease Control, 17182 Solna, Sweden, and the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.

Abstract: The formation of extracellular traps (ETs) by neutrophils and mast cells is an important mechanism in the innate immune response. These structures consist of a chromatin-DNA backbone with attached antimicrobial peptides and enzymes that trap and kill microbes. After stimulation of neutrophils and mast cells with phorbol esters, chemoattractant peptides, or chemokines, the generation of reactive oxygen species (ROS), such as hydrogen peroxide, by NAPDH [nicotinamide adenine dinucleotide phosphate (reduced form)] oxidase initiates a signaling cascade that leads to the disintegration of the nuclear and cellular membranes and the formation of ETs. This form of cell death is neither apoptotic nor necrotic, but whether it occurs because of the oxidation of phosphatases and kinases, as in other ROS-mediated signaling cascades, remains to be elucidated. These findings implicate "ETosis" as a novel cell death pathway in leukocytes.

*Corresponding author. E-mail, Birgitta.Henriques{at}smi.ki.se

Citation: F. Wartha, B. Henriques-Normark, ETosis: A Novel Cell Death Pathway. Sci. Signal. 1, pe25 (2008).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 {alpha}.
A. M. McInturff, M. J. Cody, E. A. Elliott, J. W. Glenn, J. W. Rowley, M. T. Rondina, and C. C. Yost (2012)
Blood 120, 3118-3125
   Abstract »    Full Text »    PDF »
Afa/Dr Diffusely Adhering Escherichia coli Strain C1845 Induces Neutrophil Extracellular Traps That Kill Bacteria and Damage Human Enterocyte-Like Cells.
V. Marin-Esteban, I. Turbica, G. Dufour, N. Semiramoth, A. Gleizes, R. Gorges, I. Beau, A. L. Servin, V. Lievin-Le Moal, C. Sandre, et al. (2012)
Infect. Immun. 80, 1891-1899
   Abstract »    Full Text »    PDF »
Glutathione Reductase Facilitates Host Defense by Sustaining Phagocytic Oxidative Burst and Promoting the Development of Neutrophil Extracellular Traps.
J. Yan, X. Meng, L. M. Wancket, K. Lintner, L. D. Nelin, B. Chen, K. P. Francis, C. V. Smith, L. K. Rogers, and Y. Liu (2012)
J. Immunol. 188, 2316-2327
   Abstract »    Full Text »    PDF »
Innate Immune Collectin Surfactant Protein D Simultaneously Binds Both Neutrophil Extracellular Traps and Carbohydrate Ligands and Promotes Bacterial Trapping.
D. N. Douda, R. Jackson, H. Grasemann, and N. Palaniyar (2011)
J. Immunol. 187, 1856-1865
   Abstract »    Full Text »    PDF »
Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis.
A. M. Lin, C. J. Rubin, R. Khandpur, J. Y. Wang, M. Riblett, S. Yalavarthi, E. C. Villanueva, P. Shah, M. J. Kaplan, and A. T. Bruce (2011)
J. Immunol. 187, 490-500
   Abstract »    Full Text »    PDF »
Antimicrobial Peptides Increase Tolerance to Oxidant Stress in Drosophila melanogaster.
H. W. Zhao, D. Zhou, and G. G. Haddad (2011)
J. Biol. Chem. 286, 6211-6218
   Abstract »    Full Text »    PDF »
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.
C. Guiducci, C. Tripodo, M. Gong, S. Sangaletti, M. P. Colombo, R. L. Coffman, and F. J. Barrat (2010)
J. Exp. Med. 207, 2931-2942
   Abstract »    Full Text »    PDF »
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps.
P. Li, M. Li, M. R. Lindberg, M. J. Kennett, N. Xiong, and Y. Wang (2010)
J. Exp. Med. 207, 1853-1862
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882