Sci. Signal., 3 June 2008
Immunology Right Time, Right Place
Stephen J. Simpson
Science, AAAS, Cambridge CB2 1LQ, UK
Regulatory T cells are highly immunosuppressive lymphocytes that help the body avoid autoimmunity and overzealous immune reactions. However, their existence also presents a dilemma for the immune system, because they might inadvertently shut down useful pathogen-specific immune responses. Lund et al. (see the Perspective by Kassiotis and O'Garra) present evidence that suggests that regulatory T cells can in fact optimize immune responses during the early stages of infection. Using a mouse model of herpes simplex virus infection, depleting regulatory T cells delayed the arrival of the relevant immune cells at the site of infection. At the same time, inflammatory chemokines became elevated in the lymph nodes. Thus, under normal circumstances, regulatory T cells may minimize the expression of these soluble factors in the lymph nodes so as to redirect immune cells for a timely arrival at the site of infection.
Citation: S. J. Simpson, Right Time, Right Place. Sci. Signal. 1, ec205 (2008).
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