Sci. Signal., 24 June 2008
Cell Cycle Regulating the Regulators
L. Bryan Ray
Science, Science Signaling, AAAS, Washington, DC 20005, USA
Much of the control of cell division comes down to turning on or off the activity of the cyclin-dependent kinases. Seki et al. help clarify how the transition from the G2 phase of the cell cycle into mitosis is controlled in mammalian somatic cells. The depletion of Bora, a protein encoded by a gene actively transcribed at the G2 phase of the cell cycle, prevented activation of another key kinase in cell cycle control, polo-like kinase 1 (Plk1). Bora directly interacted with Plk1, enhancing phosphorylation of Plk1 by yet another kinase that plays a role in cell cycle regulation, Aurora A.
A. Seki, J. A. Coppinger, C.-Y. Jang, J. R. Yates III, G. Fang, Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry. Science 320, 1655-1658 (2008). [Abstract] [Full Text]
Citation: L. B. Ray, Regulating the Regulators. Sci. Signal. 1, ec231 (2008).
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