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Sci. Signal., 8 July 2008
Vol. 1, Issue 27, p. ec250
[DOI: 10.1126/scisignal.127ec250]


Biochemistry Myosins Under Tension

Valda J. Vinson

Science, AAAS, Washington, DC 20005, USA

Myosin I is a single-headed myosin molecule that plays a role in regulating membrane dynamics and structure in eukaryotic cells. Its best-characterized function is to provide tension to sensitize mechanosensitive ion channels responsible for hearing. Myosin I is thought to function by sensing tension and changing its motile properties in response to changes in loads. Laakso et al. used single-molecule measurements to characterize the motor activity of myosin I. Small resisting loads (<2 pN) resulted in a 75 times lower rate of myosin I detachment from actin, dramatically changing its motor properties. This acute sensitivity supports models in which myosin I functions as a molecular force sensor.

J. M. Laakso, J. H. Lewis, H. Shuman, E. M. Ostap, Myosin I can act as a molecular force sensor. Science 321, 133-136 (2008). [Abstract] [Full Text]

Citation: V. J. Vinson, Myosins Under Tension. Sci. Signal. 1, ec250 (2008).

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