Sci. Signal., 8 July 2008
Biochemistry Myosins Under Tension
Valda J. Vinson
Science, AAAS, Washington, DC 20005, USA
Myosin I is a single-headed myosin molecule that plays a role in regulating membrane dynamics and structure in eukaryotic cells. Its best-characterized function is to provide tension to sensitize mechanosensitive ion channels responsible for hearing. Myosin I is thought to function by sensing tension and changing its motile properties in response to changes in loads. Laakso et al. used single-molecule measurements to characterize the motor activity of myosin I. Small resisting loads (<2 pN) resulted in a 75 times lower rate of myosin I detachment from actin, dramatically changing its motor properties. This acute sensitivity supports models in which myosin I functions as a molecular force sensor.
Citation: V. J. Vinson, Myosins Under Tension. Sci. Signal. 1, ec250 (2008).
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