Sci. Signal., 15 July 2008
Microbiology Know Thyself
Science, AAAS, Cambridge CB2 1LQ, UK
Cells of the pathogenic bacterium Proteus mirabilis clump together to form colonies that, on meeting other colonies, can distinguish self from foreigners. Proteus detects, then deters, interlopers of the same species using polypeptide weapons called proticines. Gibbs et al. investigated the genetic basis of this self-non-self recognition system in Proteus and discovered a locus of six genes that seem to constitute general and specific recognition determinants, as well as accessory genes. Within infected hosts, P. mirabilis infections are usually clonal, so this recognition system could be a way for an established clone to prevent superinfection by another clone and to avoid competition.
Citation: C. Ash, Know Thyself. Sci. Signal. 1, ec258 (2008).
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