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Sci. Signal., 22 January 2008
Vol. 1, Issue 3, p. ec26
[DOI: 10.1126/stke.13ec26]

EDITORS' CHOICE

Development Heads or Tails

Beverly A. Purnell

Science, AAAS, Washington, DC 20005, USA

Planarians--tubular flatworms--can regenerate all of their body parts and entire organ systems after amputation. However, the mechanism by which the animal "knows" how to generate a head after head removal or a tail after tail removal, a property called regeneration polarity, is unknown. Gurley et al. and Petersen and Reddien now find that a conserved factor within the Wnt signaling pathway is used to distinguish head from tail. Decreased Wnt signaling through β-catenin causes the regeneration of heads, whereas activation of Wnt signaling induces tails. β-catenin also maintains the anteroposterior body axis in uncut animals.

K. A. Gurley, J. C. Rink, A. Sánchez Alvarado, β-catenin defines head versus tail identity during planarian regeneration and homeostasis. Science 319, 323-327 (2008). [Abstract] [Full Text]

C. P. Petersen, P. W. Reddien, Smedcatenin-1 is required for anteroposterior blastema polarity in planarian regeneration. Science 319, 327-330 (2008). [Abstract] [Full Text]

Citation: B. A. Purnell, Heads or Tails. Sci. Signal. 1, ec26 (2008).



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