Sci. Signal., 22 January 2008
Cell Biology Tumor Suppressor Yin-Yang
Beverly A. Purnell
Science, AAAS, Washington, DC 20005, USA
The Wnt signal transduction pathway is a critical player in the development of animals. However, inappropriate activation of this pathway triggers tumorigenesis; for example, disruption of the adenomatous polyposis coli (APC) tumor suppressor, a negative regulator of Wnt signaling, results in colorectal carcinoma development. Although APC is well known to function in inhibiting gene expression, Takacs et al. now report that fruit fly homologs of APC have an opposing job in the activation of Wnt signaling. Separable domains in APC not only restrained inappropriate signaling when the Wnt signal was absent but also promoted signaling upon Wnt stimulation.
C. M. Takacs, J. R. Baird, E. G. Hughes, S. S. Kent, H. Benchabane, R. Paik, Y. Ahmed, Dual positive and negative regulation of Wingless signaling by adenomatous polyposis coli. Science 319, 333-336 (2008). [Abstract] [Full Text]
Citation: B. A. Purnell, Tumor Suppressor Yin-Yang. Sci. Signal. 1, ec28 (2008).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882