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Sci. Signal., 29 July 2008
Vol. 1, Issue 30, p. pe36
[DOI: 10.1126/scisignal.130pe36]


A New TRADDition in Intracellular Antiviral Signaling

Eric M. Pietras1 and Genhong Cheng1,2*

1Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
2Molecular Biology Institute and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, USA.

Abstract: To effectively defeat viral infection, a mammalian host must detect the presence of viruses and activate a robust antiviral response, which is mediated by cytokines known as type I interferons (IFNs). Much excitement has been generated by the discovery of the retinoic acid–induced gene 1–like helicase (RLH) pathway, which detects RNA-containing viruses in the cytoplasm and activates the type I IFN response. A study now describes a role for the tumor necrosis factor receptor (TNFR)–associated death domain (TRADD) in the antiviral response and sheds new light on how the RLH signaling complex is organized upon viral infection.

*Corresponding author. E-mail: gcheng{at}

Citation: E. M. Pietras, G. Cheng, A New TRADDition in Intracellular Antiviral Signaling. Sci. Signal. 1, pe36 (2008).

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