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Sci. Signal., 2 September 2008
Vol. 1, Issue 35, p. re9
[DOI: 10.1126/scisignal.135re9]

REVIEWS

Alternative Wnt Signaling Is Initiated by Distinct Receptors

Renée van Amerongen*, Amanda Mikels*, and Roel Nusse{dagger}

Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

* These authors contributed equally to this work.

Abstract: An unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ligand-receptor binding likely dictates the outcome of downstream signaling events. Unfortunately, possible complexities underlying ligand-receptor interactions are often overlooked. Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example.

{dagger} Corresponding author. E-mail: rnusse{at}stanford.edu

Citation: R. van Amerongen, A. Mikels, R. Nusse, Alternative Wnt Signaling Is Initiated by Distinct Receptors. Sci. Signal. 1, re9 (2008).

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