Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 16 September 2008
Vol. 1, Issue 37, p. ec328
[DOI: 10.1126/scisignal.137ec328]


Cell Biology Open and Closed Case

Stella M. Hurtley

Science, AAAS, Cambridge CB2 1LQ, UK

Calcium-triggered synaptic vesicle membrane fusion is driven by so-called SNARE proteins and Sec1/Munc18-like proteins. Gerber et al. use mouse genetics in combination with electron microscopy and electrophysiology to investigate the function of the evolutionarily conserved Munc18-syntaxin complex in fusion. In mutant mice that express only "open" syntaxin-1 that cannot bind Munc18-1 but still forms SNARE-complexes and Munc18-SNARE-complexes, the Munc18-1-syntaxin-1 complex is selectively essential for tethering synaptic vesicles and for controlling the rate of fusion of these vesicles. Thus, in vivo, syntaxin-1 function goes beyond catalyzing fusion but also regulates fusion.

S. H. Gerber, J.-C. Rah, S.-W. Min, X. Liu, H. de Wit, I. Dulubova, A. C. Meyer, J. Rizo, M. Arancillo, R. E. Hammer, M. Verhage, C. Rosenmund, T. C. Südhof, Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science 321, 1507-1510 (2008). [Abstract] [Full Text]

Citation: S. M. Hurtley, Open and Closed Case. Sci. Signal. 1, ec328 (2008).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882