Sci. Signal., 7 October 2008
Biochemistry Homing In on the Hub
Valda J. Vinson
Science, AAAS, Washington, DC 20005, USA
Microorganisms respond to a variety of environmental stresses by up-regulating stress-response genes. In many cases, the response is coordinated by a multiprotein signaling hub, the stressosome, which integrates multiple inputs to effect a single outcome. Marles-Wright et al. have fitted high-resolution structures of the stressosome components into an electron microscopy structure to determine a pseudo-atomic resolution structure of the stressosome from Bacillus subtilis. The complex has an icosohedral virus capsid–like core with 20 protruding turrets. Sequences comprising the turrets are variable, perhaps allowing them to sense different signals. The conserved domains of the core may integrate these signals to give a single signaling outcome.
J. Marles-Wright, T. Grant, O. Delumeau, G. van Duinen, S. J. Firbank, P. J. Lewis, J. W. Murray, J. A. Newman, M. B. Quin, P. R. Race, A. Rohou, W. Tichelaar, M. van Heel, R. J. Lewis, Molecular architecture of the "stressosome," a signal integration and transduction hub. Science 322, 92-96 (2008). [Abstract] [Full Text]
Citation: V. J. Vinson, Homing In on the Hub. Sci. Signal. 1, ec351 (2008).
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