Science Signaling Podcast: 11 November 2008

Michael B. Major¹, Randall T. Moon¹, and Annalisa M. VanHook²

¹ Howard Hughes Medical Institute, Department of Pharmacology, and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
² Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This is a conversation with two of the authors of a Research Article published in the 11 November issue of Science Signaling. They explain how combining a functional genetics screen with proteomics data provides new insight into Wnt signaling in a particular human cell line.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

PRESENTATIONS
Bioinformatics
Integrative Analysis of Genome-Wide RNA Interference Screens

Jason D. Berndt, Travis L. Biechele, Randall T. Moon, and Michael B. Major (12 May 2009)
Sci. Signal. 2 (70), pt4. [DOI: 10.1126/scisignal.270pt4]
 |  Abstract »  |  Full Text »  |  PDF »  |  Slideshow »

EDITORS' CHOICE
Wnt Signaling
No Oxygen, No Wnt

Wei Wong (25 November 2008)
Sci. Signal. 1 (47), ec401. [DOI: 10.1126/scisignal.147ec401]
 |  Abstract »

RESEARCH ARTICLES
Genomic Screening
New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening

Michael B. Major, Brian S. Roberts, Jason D. Berndt, Shane Marine, Jamie Anastas, Namjin Chung, Marc Ferrer, XianHua Yi, Cristi L. Stoick-Cooper, Priska D. von Haller, Lorna Kategaya, Andy Chien, Stephane Angers, Michael MacCoss, Michele A. Cleary, William T. Arthur, and Randall T. Moon (11 November 2008)
Sci. Signal. 1 (45), ra12. [DOI: 10.1126/scisignal.2000037]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

REVIEWS
Cell Biology
Alternative Wnt Signaling Is Initiated by Distinct Receptors

Renée van Amerongen, Amanda Mikels, and Roel Nusse (2 September 2008)
Sci. Signal. 1 (35), re9. [DOI: 10.1126/scisignal.135re9]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »

CONNECTIONS MAP OVERVIEWS
STKE Connections Map Overview
Wnt/β-Catenin Pathway

Randall T. Moon (15 February 2005)
Sci. STKE 2005 (271), cm1. [DOI: 10.1126/stke.2712005cm1]
 |  Abstract »  |  Full Text »  |  PDF »  |  Pathway »  |  Molecular Fat Switch »  |  Wnt Signaling Animations »  |  Human Diseases Table »

CONNECTIONS MAP OVERVIEWS
STKE Connections Map Overview
Xenopus Egg Wnt/β-Catenin Pathway

Randall T. Moon (15 February 2005)
Sci. STKE 2005 (271), cm2. [DOI: 10.1126/stke.2712005cm2]
 |  Abstract »  |  Full Text »  |  PDF »  |  Pathway »  |  Animation »

CONNECTIONS MAP OVERVIEWS
STKE Connections Map Overview
Wnt Signaling Pathways Mediated by Ca²⁺ and Cyclic GMP

Hsien-yu Wang and Craig C. Malbon (9 September 2003)
Sci. STKE 2003 (199), cm15. [DOI: 10.1126/scisignal.1992003cm15]
 |  Abstract »  |  Pathway »