Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 2 December 2008
Vol. 1, Issue 48, p. ec414
[DOI: 10.1126/scisignal.148ec414]


Nuclear Receptors It’s a Knock Out

L. Bryan Ray

Science, Science Signaling, AAAS, Washington, DC 20005, USA

The steroid receptor coactivator 2 (SRC-2) protein is well known for its function in activating transcription as a partner of the progesterone receptor. Chopra et al. describe analysis of mice lacking SRC-2 that reveals a role for the coactivator in glucose metabolism and expression of the gene encoding glucose-6-phosphatase. The knockout animals have similar characteristics to those of humans with Von Gierke’s disease, which is caused by mutations in glucose-6-phosphatase. In this context, it appears that SRC-2 may function to assist retinoid-related orphan receptor alpha (a nuclear hormone receptor related to the progesterone receptor), which binds to the promoter of the glucose-6-phosphatase gene and enhances its expression.

A. R. Chopra, J.-F. Louet, P. Saha, J. An, F. DeMayo, J. Xu, B. York, S. Karpen, M. Finegold, D. Moore, L. Chan, C. B. Newgard, B. W. O’Malley, Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke’s disease. Science 322, 1395–1399 (2008). [Abstract] [Full Text]

Citation: L. B. Ray, It’s a Knock Out. Sci. Signal. 1, ec414 (2008).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882