Science Signaling Podcast: 16 December 2008

John F. Foley and Annalisa M. VanHook

Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA

Abstract: This conversation is about research highlighted in the Editors’ Choice summary titled "Under Cover." The highlighted articles are C. Xu, E. Gagnon, M. E. Call, J. R. Schnell, C. D. Schwieters, C. V. Carman, J. J. Chou, K. W. Wucherpfennig, Regulation of T cell receptor activation by dynamic membrane binding of the CD3 cytoplasmic tyrosine-based motif. Cell 135, 702–713 (2008); and M. S. Kuhns, M. M. Davis, The safety on the TCR trigger. Cell 135, 594–596 (2008).

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH
Immunology
Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3

Nuria Martínez-Martín, Ruth M. Risueño, Antonio Morreale, Irene Zaldívar, Elena Fernández-Arenas, Fernando Herranz, Angel R. Ortiz, and Balbino Alarcón (11 August 2009)
Sci. Signal. 2 (83), ra43. [DOI: 10.1126/scisignal.2000402]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORS' CHOICE
Immunology
Under Cover

John F. Foley (18 November 2008)
Sci. Signal. 1 (46), ec390. [DOI: 10.1126/scisignal.146ec390]
 |  Abstract »

EDITORS' CHOICE
Immunology
Getting the Numbers Right

John F. Foley (27 May 2008)
Sci. Signal. 1 (21), ec194. [DOI: 10.1126/stke.121ec194]
 |  Abstract »

PERSPECTIVES
Receptors
TCR Triggering by the pMHC Complex: Valency, Affinity, and Dynamics

Rajat Varma (13 May 2008)
Sci. Signal. 1 (19), pe21. [DOI: 10.1126/stke.119pe21]
 |  Abstract »  |  Full Text »  |  PDF »

REVIEWS
Immunology
The Expanding Role for ITAM-Based Signaling Pathways in Immune Cells

Clare L. Abram and Clifford A. Lowell (13 March 2007)
Sci. STKE 2007 (377), re2. [DOI: 10.1126/stke.3772007re2]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »