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Sci. Signal., 23 December 2008
Vol. 1, Issue 51, p. mr3
[DOI: 10.1126/scisignal.151mr3]


Regulatory T Cells: The Cunning Fox and Its Clinical Application

David S. Game1, Xuetao Cao2, and Shuiping Jiang3*

1 Department of Renal Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
2 Institute of Immunology, Second Military Medical University, Shanghai, China.
3 Department of Nephrology and Transplantation, King’s College London, Guy’s Hospital, London SE1 9RT, UK.

Selected highlights from the International Conference on Regulatory T Cells and Clinical Application in Human Diseases: "China Tregs 2008," Beijing, China, 25 to 27 October 2008.

Abstract: So profound is the potential for regulatory T cells (Tregs) to control unwanted immune responses that in 2008 an entire conference was dedicated to them. The underlying concept of this conference, "China Tregs 2008," was that unraveling the cellular biology of Tregs will lead to important advances for therapies in virtually all human disease processes and in transplantation. The master-switch of immune regulation is the forkhead transcription factor Foxp3; in mice, Foxp3 is a sine qua non for regulatory activity. At "China Tregs 2008," the cell signaling events leading to the expression of Foxp3 and those events downstream were explored together with presentations on how the latest knowledge of the biology of Tregs is being translated in the clinic.

* Corresponding author. E-mail: shuiping.jiang{at}

Citation: D. S. Game, X. Cao, S. Jiang, Regulatory T Cells: The Cunning Fox and Its Clinical Application. Sci. Signal. 1, mr3 (2008).

Read the Full Text

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