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Sci. Signal., 23 December 2008
Vol. 1, Issue 51, p. pe54
[DOI: 10.1126/scisignal.151pe54]

PERSPECTIVES

Bursting into the Nucleus

Gerald R. Crabtree and Isabella A. Graef*

Stanford University Medical School, Stanford, CA 94305, USA.

Abstract: An increase in extracellular Ca2+ induces the nuclear localization of the Crz1 transcription factor and the activation of target genes in yeast. A recent study indicates that nuclear entry occurs in short stochastic bursts that are unsynchronized within the population of cells. The frequency but not the amplitude of the bursts is controlled by Ca2+. Modulation of the frequency of the burst coordinates aspects of expression of Crz target genes.

* Corresponding author. E-mail, igraef{at}stanford.edu

Citation: G. R. Crabtree, I. A. Graef, Bursting into the Nucleus. Sci. Signal. 1, pe54 (2008).

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