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Sci. Signal., 23 December 2008
Vol. 1, Issue 51, p. pe55
[DOI: 10.1126/scisignal.1.51.pe55]
PERSPECTIVES
Untangling the Complex Web of IL-4– and IL-13–Mediated Signaling Pathways
Marsha Wills-Karp1* and
Fred D. Finkelman1,2
1 Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 45229, USA. 2 Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0555, USA, and Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA.
Abstract:
Unraveling the exact signaling events mediating the distinct functions of the T cell–derived cytokines interleukin-4 (IL-4) and IL-13 has been challenging because they are structurally similar and share a functional signaling receptor chain. A study now proposes a potential molecular mechanism to explain the functional differences between IL-4 and IL-13 that involves the ability of IL-4, but not IL-13, to effectively activate the insulin receptor substrate–2 (IRS-2) signaling cascade through binding to its receptor. A better understanding of the interactions of IL-4 and IL-13 with their cognate receptors may facilitate the development of therapies without unintended side effects.
The editors suggest the following Related Resources on Science sites:
In Science Signaling
EDITORIAL GUIDES
John F. Foley and Nancy R. Gough (19 January 2010) Sci. Signal.3 (105), eg2.
[DOI: 10.1126/scisignal.3105eg2] |Abstract »|Full Text »|PDF »
RESEARCH ARTICLES
Nicola M. Heller, Xiulan Qi, Ilkka S. Junttila, Kari Ann Shirey, Stefanie N. Vogel, William E. Paul, and Achsah D. Keegan (23 December 2008) Sci. Signal.1 (51), ra17.
[DOI: 10.1126/scisignal.1164795] |Editor's Summary »|Abstract »|Full Text »|PDF »
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