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Sci. Signal., 12 February 2008
Vol. 1, Issue 6, p. pe7
[DOI: 10.1126/stke.16pe7]


Novel Roles for the NF-{kappa}B Signaling Pathway in Regulating Neuronal Function

Matt C. Boersma and Mollie K. Meffert*

Departments of Biological Chemistry and Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

Abstract: Two new reports offer exciting evidence of novel roles for components of the nuclear factor {kappa}B (NF-{kappa}B) pathway in the nervous system. Transcriptional activation by NF-{kappa}B and chromatin remodeling by inhibitor of {kappa}B (I{kappa}B) kinase complex (IKK) have been linked to recall and reconsolidation of conditioned fear memories in the mammalian central nervous system. In the Drosophila neuromuscular junction, a member of the NF-{kappa}B family has been reported to regulate glutamate receptor clustering. Both reports could have important implications for the function of the NF-{kappa}B signaling pathway in neuronal plasticity.

*Corresponding author. E-mail, mkm{at}

Citation: M. C. Boersma, M. K. Meffert, Novel Roles for the NF-{kappa}B Signaling Pathway in Regulating Neuronal Function. Sci. Signal. 1, pe7 (2008).

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