Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 19 February 2008
Vol. 1, Issue 7, p. ec67
[DOI: 10.1126/stke.17ec67]


Evolution Cadherins on the Road to Multicellularity

Laura M. Zahn

Science, AAAS, Washington, DC 20005, USA

How early organisms made the transition from unicellularity to multicellularity is unknown, although certain genes have been implicated as important players in this process. One such group is the cadherin family of genes that function in cell adhesion and cell-cell signaling. By examining the genome of the unicellular choanoflagellate Monosiga brevicollis, Abedin and King show that the genome of M. brevicollis contains 23 expressed cadherin genes--as many as several multicellular animals. At least two of the cadherins localized to the actin-filled microvilli of the protozoan feeding collar, where they may participate in the recognition and capture of bacterial prey.

M. Abedin, N. King, The premetazoan ancestry of cadherins. Science 319, 946-948 (2008). [Abstract] [Full Text]

Citation: L. M. Zahn, Cadherins on the Road to Multicellularity. Sci. Signal. 1, ec67 (2008).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882