Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 19 February 2008
Vol. 1, Issue 7, p. ec68
[DOI: 10.1126/stke.17ec68]


Medicine Full Metal Abscess

Stephen J. Simpson

Science, AAAS, Cambridge CB2 1LQ, UK

Tissue abscesses form when bacteria meet cells of the immune system, most notably neutrophils. Corbin et al. (see the Perspective by Novick) now find that the abundant neutrophil protein, calprotectin, protects the host against bacterial growth by chelating metal ions used by the bacteria as nutrients. In mice during bacterial infection, calprotectin was localized to tissue abscesses, where it chelated manganese and zinc ions. Infected mice lacking calprotectin had elevated metal levels and increased bacterial growth in tissue abscesses.

B. D. Corbin, E. H. Seeley, A. Raab, J. Feldmann, M. R. Miller, V. J. Torres, K. L. Anderson, B. M. Dattilo, P. M. Dunman, R. Gerads, R. M. Caprioli, W. Nacken, W. J. Chazin, E. P. Skaar, Metal chelation and inhibition of bacterial growth in tissue abscesses. Science 319, 962-965 (2008). [Abstract] [Full Text]

R. P. Novick, Combating impervious bugs. Science 319, 910-911 (2008). [Summary] [Full Text]

Citation: S. J. Simpson, Full Metal Abscess. Sci. Signal. 1, ec68 (2008).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882