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Sci. Signal., 19 February 2008
Vol. 1, Issue 7, p. tr1
[DOI: 10.1126/stke.17tr1]


Quantitative Models of Mammalian Cell Signaling Pathways

Ravi Iyengar*

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract: This teaching resource provides lecture notes and slides for a class on mathematical modeling of mammalian signaling pathways. This lecture was part of the course "Cell Signaling Systems: A Course for Graduate Students" and focused on quantitative modeling. The lecture describes how different types of mathematical representations are applied to different signaling systems to provide insight into how a signaling system controls cell behavior. The development of an ordinary differential equation–based model for a bistable switch and the predictions that can be obtained from the model are described. The lecture concludes with a description of how models can be tested experimentally and modified when the details of the models and the resultant predictive behavior are not confirmed by experimentation.

*Contact information. E-mail, ravi.iyengar{at}

Citation: R. Iyengar, Quantitative Models of Mammalian Cell Signaling Pathways. Sci. Signal. 1, tr1 (2008).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882