Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 4 March 2008
Vol. 1, Issue 9, p. pe12
[DOI: 10.1126/stke.19pe12]


Meeting Report: cGMP Matters

Barbara Kemp-Harper1* and Robert Feil2

1Department of Pharmacology and Centre for Vascular Health, Monash University, Clayton, Victoria, Australia.
2Interfakultäres Institut für Biochemie, Universität Tübingen, Tübingen, Germany.

A report on the 3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications, Dresden, Germany, 15 to 17 June 2007.

Abstract: The second messenger cyclic guanosine 3',5'-monophosphate (cGMP) controls many cellular functions ranging from growth to contractility. Generated from guanylyl cyclases in response to natriuretic peptides or nitric oxide, cGMP transduces its effects through a number of cGMP effectors, including cGMP-regulated phosphodiesterases and protein kinases. Drugs that modulate cGMP levels are emerging as promising therapies, particularly for cardiovascular disorders. This report summarizes new data on the molecular mechanisms, (patho)physiological relevance, and therapeutic potential of the cGMP signaling system that were presented at the 3rd cGMP meeting held in June 2007 in Dresden, Germany.

*Corresponding author. E-mail: Barbara.Kemp{at}

Citation: B. Kemp-Harper, R. Feil, Meeting Report: cGMP Matters. Sci. Signal. 1, pe12 (2008).

Read the Full Text

Transgenic Mice for cGMP Imaging.
M. Thunemann, L. Wen, M. Hillenbrand, A. Vachaviolos, S. Feil, T. Ott, X. Han, D. Fukumura, R. K. Jain, M. Russwurm, et al. (2013)
Circ. Res. 113, 365-371
   Abstract »    Full Text »    PDF »
The Commonly Used cGMP-dependent Protein Kinase Type I (cGKI) Inhibitor Rp-8-Br-PET-cGMPS Can Activate cGKI in Vitro and in Intact Cells.
N. Valtcheva, P. Nestorov, A. Beck, M. Russwurm, M. Hillenbrand, P. Weinmeister, and R. Feil (2009)
J. Biol. Chem. 284, 556-562
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882