Sci. STKE, 28 September 1999
Plant biology Degrading in the light
Like animals, bacteria, and chlorophyll-containing plants, the filamentous fungus Neurospora crassa also responds to light. White collar-1 (WC-1) and white collar 2 (WC-2) are transcription factors that maintain the circadian cycle of Neurospora and regulate expression of light-induced genes. However, it is not clear how their activity is regulated by light. Talora et al. report that under dark or light conditions, these WC proteins form a complex in vivo. However, upon exposure to light, WC-1 becomes hyperphosphorylated, a modification that then triggers its release from the WC complex and its subsequent degradation. Newly synthesized WC-1 then takes its place. This observation suggests that transcription factor turnover is one mechanism by which gene expression is regulated by light.
Citation: Degrading in the light. Sci. STKE 1999, tw1 (1999).
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