Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 28 September 1999
Vol. 1999, Issue 1, p. tw13
[DOI: 10.1126/stke.1999.1.tw13]


Transcription factors All in the family

Mutations in the tumor suppressor protein APC inappropriately activate the transcription factor Tcf4, which in turn activates genes that cause intestinal epithelial cells to become transformed into cancer cells. Roose et al. show that the gene encoding another member of this transcription factor family, Tcf1, is a direct target of Tcf4. Tcf1 acts as a feedback repressor of Tcf4 by antagonizing its effects on cell transformation. Thus, Tcf1 cooperates with APC in suppressing tumorigenesis.

Roose, J., Huls, G., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., Clevers, H. (1999) Synergy between tumor suppressor APC and the ?-catenin -Tcf4 target Tcf1. Science 285: 1923-1925. [Abstract] [Full Text]

Citation: All in the family. Sci. STKE 1999, tw13 (1999).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882