Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Signaling - Call For Papers

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 28 September 1999
Vol. 1999, Issue 1, p. tw2
[DOI: 10.1126/stke.1999.1.tw2]

EDITORS' CHOICE

Stopping Smads in the nucleus

Abstract: One potent effect of the cytokine transforming growth factor-ß (TGFß) is to arrest growth in certain cell types. Upon activation by its ligand, the TGFß receptor induces the formation of a heterocomplex of the Smad 2, 3, and 4 proteins in the cytosol. The Smad complex then translocates into the nucleus to activate TGFß -responsive genes. Luo et al. report that a nuclear protein called Ski binds to and inhibits the Smad complex. Ski itself is a transcription regulator and is implicated in cell growth control. Ski expression repressed TGFß-induced inhibition of cell growth. Smad-Ski interaction may therefore be one mechanism by which both TGFß signaling is disabled and the transforming activity of Ski is promoted.

Luo, K., Stroschein, S.L., Wang, W., Chen, D., Martens, E., Zhou, S., Zhou, Q. (1999) The Ski oncoprotein interacts with Smad proteins to repress TGFß?signaling. Genes Dev. 13: 2196-2206. [Abstract] [Full Text]

Citation: Stopping Smads in the nucleus. Sci. STKE 1999, tw2 (1999).

Read the Full Text

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)