Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 28 September 1999
Vol. 1999, Issue 1, p. tw3
[DOI: 10.1126/stke.1999.1.tw3]


Signaling framework Wnt cascade gains dishevelled kinase

Wnt is a secreted protein that binds to receptors of the Frizzled family. This interaction activates a signaling cascade that controls gene expression during cell growth and developmental processes. The known components of this cascade include the proteins dishevelled, glycogen synthase kinase-3, and β-catenin. Peters et al. reveal that in the developing frog and worm, a serine-threonine kinase called casein kinase I (CKI) functions in the Wnt signaling pathway. In Xenopus laevis, overexpression of CKI mimicked the effects of Wnt overexpression in producing a secondary dorsal axis, stabilizing β-catenin, and inducing the expression of Wnt-target genes. In Caenorhabditis elegans, inhibition of CKI produced the same mesoderm phenotype as loss of Wnt-signaling. The authors demonstrate that CKI is positioned downstream of dishevelled, and upstream of β-catenin. CKI also interacted with and phosphorylated dishevelled. It is possible that phosphorylation of dishevelled by CKI modulates downstream signaling events in the Wnt pathway.

Peters, J.M., McKay, R.M., McKay, J.P., and Graff, J.M. (1999) Casein kinase I transduces Wnt signals. Nature 401: 345-350. Online Journal

Citation: Wnt cascade gains dishevelled kinase. Sci. STKE 1999, tw3 (1999).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882