Sci. STKE, 28 September 1999
Receptor crosstalk Passing signals by sharing subunits
Although the Gα subunits of heterotrimeric G-proteins exhibit specificity for the receptors to which they couple, receptor interaction with Gβ subunits appears to be less selective. Quitterer and Lohse now report that two different G-protein coupled receptors (GPCRs) appear to communicate with each other by sharing the same Gβ. Activation of the Gαi-coupled receptor for adenosine A1 or the α2C adrenergic receptor stimulated signals that are propagated by Gαq-coupled receptors for bradykinin or UTP. The authors suggest that upon receptor stimulation, the Gαi -coupled receptor releases its Gβ to the Gαq -coupled receptor. Once docked in its new home, Gβ stimulates Gαq activation. Subunit exchange may therefore be one mechanism for crosstalk between GPCRs.
Citation: Passing signals by sharing subunits. Sci. STKE 1999, tw6 (1999).
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