Sci. STKE, 28 September 1999
Receptor biology Antagonism in the family
The receptor tyrosine kinase p185HER-2 is implicated in several human carcinomas. When overexpressed, this receptor dimerizes in the absence of a known ligand and becomes constitutively activated. This receptor can also heterodimerize with ligand-activated members of the structurally related epidermal growth factor receptor family. Doherty et al. have identified a naturally occurring inhibitor of p185HER-2 called herstatin. This secreted protein is the product of an alternatively spliced HER-2 transcript that encodes part of the receptor extracellular domain as well as residues encoded by an intron. By binding to p185HER-2, herstatin may inhibit receptor dimerization. Hence, herstatin may have value as a growth inhibitor in anti-cancer therapies.
Doherty, J.K., Bond, C., Jardim, A., Adelman, J.P., Clinton, G.M. (1999) The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor. Proc. Natl. Acad. Sci. U.S.A. 96: 10869-10874. [Abstract] [Full Text]
Citation: Antagonism in the family. Sci. STKE 1999, tw7 (1999).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882