Sci. STKE, 14 December 1999
Cell Biology Another Kinase Linked to NF-B
Tumor necrosis factor (TNF) causes activation of the transcription factor NF-B by activating TNF receptors on the cell surface. The receptor then binds TRAF adaptor proteins, which couple it to a series of kinases that ultimately lead to control of NF-B. A new family of protein kinases that are related to the I-B kinases has now been identified that may couple TRAF2 to transcriptional activation. Although its characterization has so far only been accomplished in transiently transfected cells, TBK1 (for TANK-binding kinase 1) appears to function in a complex with TRAF2 and TANK, a TRAF-binding protein. Physiological substrates for TBK1 are not yet known, but it appears to represent another important component in the complex regulation of NF-B.
Citation: Another Kinase Linked to NF-B. Sci. STKE 1999, tw2 (1999).
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