Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 19 October 1999
Vol. 1999, Issue 4, p. tw3
[DOI: 10.1126/stke.1999.4.tw3]

EDITORS' CHOICE

Calcium signaling Calcium signaling: Nuclear Reaction Makes Cyclic ADP Ribose

Ryanodine receptors, which function as calcium channels activated by binding of cyclic ADP ribose (cADPr), are present in nuclear membranes with their ligand binding sites facing the nucleoplasm. However, it has not been clear whether cADPr produced in the cytoplasm can cross nuclear membranes to reach such binding sites. Adebanjo et al. now report that ADP-ribose cyclase or CD38, the membrane-associated enzyme that generates cADPr from nicotinamide adenine dinucleotide (NAD+), is present in the inner nuclear membrane, with its catalytic region on the nucloplasmic side. In isolated nuclei from mammalian MC3T3.E1 cells treated to allow storage of calcium in the nuclear envelope, NAD+ or cADPr caused increases in the concentration of nucleoplasmic calcium. The authors propose that cADPR generated in the nucleoplasm may cause transport of calcium across the inner nuclear membrane through ryanodine receptors and could thereby influence gene expression.

Adebanjo, O.A., Anandatheerthavarada, H.K., Koval, A.P., Moonga, B.S., Biswas, G., Sun, L., Sodam, B.R., Bevis, P.J.R., Huang, C.L.-H., Epstein, S., Lai, F.A., Avadhani, N.G., and Zaidi, M. (1999) A new function for CD38/ADP-ribosyl cyclase in nuclear calcium homeostasis. Nature Cell Biol. 1: 409-414. [Online Journal]

Citation: Calcium signaling: Nuclear Reaction Makes Cyclic ADP Ribose. Sci. STKE 1999, tw3 (1999).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882