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Sci. STKE, 26 October 1999
Vol. 1999, Issue 5, p. pe1
[DOI: 10.1126/stke.1999.5.pe1]

PERSPECTIVES

Getting Directions: Axon Guidance Receptors Find the Way

David C. Merz and Joseph G. Culotti1

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada, and Department of Medical and Molecular Genetics, Faculty of Medicine, University of Toronto, Ontario M5G 1X5, Canada.

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1 To whom correspondence should be addressed (at Mount Sinai Hospital). E-mail: culotti{at}mshri.on.ca

Abstract: As neuronal growth cones explore the terrain, their migration is dictated by guidance cues in the environment. Some cues are considered bifunctional because they can elicit an attractive or repulsive response. However, the cytoplasmic tails of guidance cue receptors appear to also control how growth cones respond. Merz and Culotti discuss recent evidence that the cytoplasmic domains of the DCC and UNC-5 family of receptors control the response of neurons to netrins, and propose a model for mechanisms by which axon guidance receptors might function.

Citation: D. C. Merz, J. G. Culotti, Getting Directions: Axon Guidance Receptors Find the Way. Sci. STKE 1999, pe1 (1999).

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