Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 23 November 1999
Vol. 1999, Issue 9, p. tw5
[DOI: 10.1126/stke.1999.9.tw5]

EDITORS' CHOICE

Signal News Gilman to Form Alliance for Cell Signaling

The man who introduced us to G proteins looks to have another trick up his sleeve--a "big science" approach to signal transduction that may reveal the big picture of how networks of signaling pathways are coordinated to control physiological processes. In the news this week, Al Gilman of the University of Texas Southwestern Medical Center has initiated a $10 million a year project to systematically explore signal transduction mechanisms in cardiac myocytes and B lymphocytes. Under the proposal currently under consideration at the National Institute of General Medical Sciences, large-scale screening of protein-protein interactions in a number of core labs would generate leads that would be immediately posted on the Internet, allowing scientists anywhere to benefit from the work. Just keeping track of the data will be a project in itself. A database, not unlike STKE's Connections Map, is envisaged with highly detailed "molecule pages" that provide a comprehensive compilation of the biochemical properties of each signaling component. This should allow quantitative analysis and, ultimately, theoretical modeling of the signaling pathways and their interactions. Get the details at http://afcs.swmed.edu.

Abbott, A. (1999) Alliance of US labs plans to build map of cell signalling pathways. Nature 402: 219-220. [Online Journal]

Citation: Gilman to Form Alliance for Cell Signaling. Sci. STKE 1999, tw5 (1999).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882