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Sci. Signal., 8 December 2009
Vol. 2, Issue 100, p. jc2
[DOI: 10.1126/scisignal.2100jc2]


To Be {gamma}{delta} or Not to Be {gamma}{delta}? Signaling Pathways in {alpha}β Versus {gamma}{delta} T Cell Maturation

Julia K. Archbold*

Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Monash University, Clayton, Victoria 3800, Australia.

Abstract: Maturation of T cells in the thymus involves input from a number of signaling pathways; their combined input determines whether thymic precursor cells will differentiate into mature {alpha}β or {gamma}{delta} T cells. This Journal Club article highlights recent research showing that the role of Notch signaling in human T cell maturation differs from that in mice. In mice, reducing Notch gene dosage in vivo promotes {gamma}{delta} T cell differentiation. In humans, an increase in Notch activity early in development will trigger {gamma}{delta} T cell development. This research emphasizes how the molecular events controlling T cell development are fundamentally different in humans and mice.

* Corresponding author. E-mail, julia.archbold{at}

Citation: J. K. Archbold, To Be {gamma}{delta} or Not to Be {gamma}{delta}? Signaling Pathways in {alpha}β Versus {gamma}{delta} T Cell Maturation. Sci. Signal. 2, jc2 (2009).

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Specific Notch receptor-ligand interactions control human TCR-{alpha}{beta}/{gamma}{delta} development by inducing differential Notch signal strength.
I. Van de Walle, E. Waegemans, J. De Medts, G. De Smet, M. De Smedt, S. Snauwaert, B. Vandekerckhove, T. Kerre, G. Leclercq, J. Plum, et al. (2013)
J. Exp. Med. 210, 683-697
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