Sci. Signal., 13 January 2009
Cell Biology CD30-ARNT Interaction
L. Bryan Ray
Science, Science Signaling, AAAS, Washington, DC 20005, USA
CD30 is a member of the tumor necrosis factor receptor (TNFR) family associated with certain cancers of lymphoid cells. In a screen for proteins that interact with CD30, Wright and Duckett identified ARNT, the aryl hydrocarbon receptor nuclear translocator (also called hypoxia-inducible factor 1β), a transcription factor better known for its roles in mediating responses to the toxin dioxin or cellular responses to hypoxia. In a human cell line, ARNT was associated with internalized CD30. CD30 regulates gene expression in part through the transcription factor NF-B, and depletion of ARNT-enhanced NF-B–dependent transcription altered the association of NF-B subunits with target promoters. Thus, signals impinging on ARNT may indirectly alter signaling by CD30 by modulating the function of the shared ARNT signaling component.
Citation: L. B. Ray, CD30-ARNT Interaction. Sci. Signal. 2, ec16 (2009).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882