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Sci. Signal., 13 January 2009
Vol. 2, Issue 53, p. pc1
[DOI: 10.1126/scisignal.253pc1]


Science Signaling Podcast: 13 January 2009

John D. Scott1, Wei Wong2,3, and Annalisa M. VanHook3

1 Howard Hughes Medical Institute and Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue, N.E., HSB K-336B, Box 357370, Seattle, WA 98195, USA.
2 Howard Hughes Medical Institute and Vollum Institute, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USA.
3 Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This is a conversation with John Scott and Wei Wong, authors of a Research Article published in the 23 December 2008 issue of Science Signaling. They discuss their work showing that the scaffold protein muscle A kinase-anchoring protein (mAKAP) is important for localizing components that mediate the cellular response to hypoxia to the nuclear envelope. This compartmentalization of the hypoxia signaling machinery poises the hypoxia-inducible factor 1{alpha} (HIF-1{alpha}) for action in the nucleus in response to limiting oxygen conditions.

Citation: J. D. Scott, W. Wong, A. M. VanHook, Science Signaling Podcast: 13 January 2009. Sci. Signal. 2, pc1 (2009).

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