Sci. Signal., 13 January 2009
Science Signaling Podcast: 13 January 2009
John D. Scott1, Wei Wong2,3, and Annalisa M. VanHook3
1 Howard Hughes Medical Institute and Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue, N.E., HSB K-336B, Box 357370, Seattle, WA 98195, USA.
Abstract: This is a conversation with John Scott and Wei Wong, authors of a Research Article published in the 23 December 2008 issue of Science Signaling. They discuss their work showing that the scaffold protein muscle A kinase-anchoring protein (mAKAP) is important for localizing components that mediate the cellular response to hypoxia to the nuclear envelope. This compartmentalization of the hypoxia signaling machinery poises the hypoxia-inducible factor 1 (HIF-1) for action in the nucleus in response to limiting oxygen conditions.
Citation: J. D. Scott, W. Wong, A. M. VanHook, Science Signaling Podcast: 13 January 2009. Sci. Signal. 2, pc1 (2009).
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