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Sci. Signal., 20 January 2009
Vol. 2, Issue 54, p. pe4
Protein Kinase Activation Loop Autophosphorylation in Cis: Overcoming a Catch-22 Situation
Pamela A. Lochhead*
The Laboratory of Molecular Signalling, The Babraham Research Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.
Autophosphorylation of the activation loop in cis is an underappreciated and poorly understood mode of activation of protein kinases. Here, I describe four examples of protein kinases that are activated in this way, concentrating on their biochemical properties and how their autophosphorylation in cis is achieved.