Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 3 February 2009
Vol. 2, Issue 56, p. pe7
[DOI: 10.1126/scisignal.256pe7]


Bistable Switches for Synaptic Plasticity

Hideaki Ogasawara1,2* and Mitsuo Kawato2

1 National Institute of Information and Communications Technology, Seika, Kyoto 619-0288, Japan.
2 ATR Computational Neuroscience Laboratories, Seika, Kyoto 619-0288, Japan.

Abstract: A persistent decrease in synaptic efficacy, called long-term depression (LTD), of the parallel fiber–Purkinje cell synapse is thought to underlie some forms of learning and memory in the cerebellum. Simulation studies predicted that mitogen-activated protein kinase and protein kinase C would mutually activate each other and make a bistable positive feedback loop, thereby providing a molecular basis for LTD. This claim stimulated experimenters to successfully demonstrate the feedback loop and its pivotal role in cerebellar LTD.

* Corresponding author. E-mail: ogahide{at}

Citation: H. Ogasawara, M. Kawato, Bistable Switches for Synaptic Plasticity. Sci. Signal. 2, pe7 (2009).

Read the Full Text

CaMKII "Autonomy" Is Required for Initiating But Not for Maintaining Neuronal Long-Term Information Storage.
I. Buard, S. J. Coultrap, R. K. Freund, Y.-S. Lee, M. L. Dell'Acqua, A. J. Silva, and K. U. Bayer (2010)
J. Neurosci. 30, 8214-8220
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882