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Sci. Signal., 24 February 2009
Vol. 2, Issue 59, p. mr2
[DOI: 10.1126/scisignal.259mr2]


Signal Transduction Molecules as Targets for Cancer Prevention

Ann M. Bode* and Zigang Dong

The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA.

A report on the joint 3rd Hormel Institute Frontiers in Cancer Conference and 8th International Skin Carcinogenesis Conference held at The Hormel Institute, University of Minnesota, Austin, Minnesota, 4 to 7 October 2008.

Abstract: Environmental and life-style aspects are major contributors to human carcinogenesis and, therefore, many human cancers may be preventable. Cancer is the end result of defects in cellular signaling processes that play a key role in the control of cell growth, survival, division, and differentiation. Therefore, identifying molecular and cellular targets critical in cancer development and prevention is an area of intensive research, driving the development of highly specific small-molecule inhibitors. A major idea today is that cancer may be prevented or treated by targeting the products of specific cancer-related genes, frequently encoding signaling proteins or transcription factors. Participants in these joint conferences discussed their latest findings in the identification of promising molecular targets and the development of agents directed against these targets with the goal of effectively transitioning these into the clinical setting.

* Corresponding author. Telephone, 507-437-9615; fax, 507-437-9606; e-mail, ambode{at}

Citation: A. M. Bode, Z. Dong, Signal Transduction Molecules as Targets for Cancer Prevention. Sci. Signal. 2, mr2 (2009).

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Phosphorylation of Histone H2B Serine 32 Is Linked to Cell Transformation.
A. T. Y. Lau, S.-Y. Lee, Y.-M. Xu, D. Zheng, Y.-Y. Cho, F. Zhu, H.-G. Kim, S.-Q. Li, Z. Zhang, A. M. Bode, et al. (2011)
J. Biol. Chem. 286, 26628-26637
   Abstract »    Full Text »    PDF »
Update on Cancer Prevention Research in the United States and China: The 2009 China--U.S. Forum on Frontiers of Cancer Research.
A. M. Bode, Y. Cao, and Z. Dong (2010)
Cancer Prevention Research 3, 1630-1637
   Abstract »    Full Text »    PDF »

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