Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 17 March 2009
Vol. 2, Issue 62, p. ec97
[DOI: 10.1126/scisignal.262ec97]

EDITORS' CHOICE

Neuroscience Limiting Potential

Stella Hurtley

Science, AAAS, Cambridge CB2 1LQ, UK

Synapse formation is tightly controlled to achieve a specific size, shape, and number of synapses. Although recent advances have been made in discovering key molecules that are important for the initiation and maintenance of synaptic recruitment, negative regulators that restrict this aggregation to control the size and number of synapses are poorly understood. Patel and Shen have identified the evolutionarily conserved protein RSY-1 as a local inhibitor of synaptogenesis, controlling the number of presynaptic terminals and the amount of material recruited to presynaptic sites. RSY-1 inhibited synaptogenesis by antagonizing master assembly molecules essential for presynaptic development. This type of negative regulation is likely to be as important for synaptic regulation as the intensively studied mechanisms of positive regulation.

M. R. Patel, K. Shen, RSY-1 is a local inhibitor of presynaptic assembly in C. elegans. Science 323, 1500–1503 (2009). [Abstract] [Full Text]

Citation: S. Hurtley, Limiting Potential. Sci. Signal. 2, ec97 (2009).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882