Sci. Signal., 17 March 2009
Plant Biology Closing the Loop
Pamela J. Hines
Science, AAAS, Washington, DC 20005, USA
Circadian clocks keep us, and our plants, reasonably attuned to the cycle of days and nights. Analyses of the molecules in the plant Arabidopsis that achieve this steady coordination have led to interlocking networks of logic and feedback loops of gene regulation. Pruneda-Paz et al. (see the Perspective by McClung) have now used a targeted genomics approach with yeast to add another molecule to the game: the transcription factor CHE. CHE binds to already known clock components of Arabidopsis and forms a linkage that was predicted but not yet closed, namely, bringing together a known clock component, TOC1, with its expected target gene, CCA1.
Citation: P. J. Hines, Closing the Loop. Sci. Signal. 2, ec99 (2009).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882