Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 14 April 2009
Vol. 2, Issue 66, p. ec132
[DOI: 10.1126/scisignal.266ec132]

EDITORS' CHOICE

Immunology Mosquito Immune Mediation

Caroline Ash

Science, AAAS, Cambridge CB2 1LQ, UK

Mosquitoes are vectors of numerous human and animal diseases, including malaria. Approaches that enhance or otherwise alter the natural defense mechanisms of mosquitoes could help to reduce or eliminate their competence as vectors of disease. Proteins containing leucine-rich repeats (LRIM1 and APL1C) are known to mediate immune responses in the mosquito, Anopheles gambiae, against the malaria parasite, Plasmodium berghei. Povelones et al. used gene silencing to show that these proteins produce an immune cascade together with a complement-like protein, binding to the surface of the parasite targeting it for destruction. LRIM1 and APL1C are members of an extensive family of secreted leucine-rich repeats containing proteins that are unique to mosquitoes.

M. Povelones, R. M. Waterhouse, F. C. Kafatos, G. K. Christophides, Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites. Science 324, 258–261 (2009). [Abstract] [Full Text]

Citation: C. Ash, Mosquito Immune Mediation. Sci. Signal. 2, ec132 (2009).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882