Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Signal., 21 April 2009
Vol. 2, Issue 67, p. eg5
[DOI: 10.1126/scisignal.267eg5]

EDITORIAL GUIDES

Focus Issue: Demystifying mTOR Signaling

Nancy R. Gough*

Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: The mammalian target of rapamycin (mTOR) is a master integrator of cell energy state, nutrient status, and growth factor stimulation. This kinase is part of two distinct complexes, mTORC1 and mTORC2, and the network that regulates these two complexes is interconnected with distinct and overlapping inputs and outputs. Research published in Science Signaling has revealed new connections between epidermal growth factor receptors and the mTOR pathway, and new insight into the roles of mTOR signaling in vascular disease. The Perspectives in this issue highlight how new pharmacological tools and the ability to knock down the function of complex-specific subunits are providing new insight into the regulation and functions of these complexes in physiological contexts, as well as providing new avenues for therapeutic intervention in diseases associated with aberrant activity of these complexes.

* Corresponding author. E-mail: ngough{at}aaas.org

Citation: N. R. Gough, Focus Issue: Demystifying mTOR Signaling. Sci. Signal. 2, eg5 (2009).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Science Signaling Podcast: 21 April 2009.
M. B. Yaffe and A. M. VanHook (2009)
Science Signaling 2, pc8
   Abstract »    Full Text »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882