Science Signaling Podcast: 21 April 2009

Michael B. Yaffe^1,2 and Annalisa M. VanHook³

¹ Chief Scientific Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.
² David H. Koch Institute for Integrative Cancer Research, Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
³ Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This is a conversation with Michael Yaffe, Chief Scientific Editor of Science Signaling. He discusses signaling through the mammalian target of rapamycin (mTOR) pathway, the topic of a Science Signaling Focus Issue released this week.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORIAL GUIDES
Cell Biology
Focus Issue: Demystifying mTOR Signaling

Nancy R. Gough (21 April 2009)
Sci. Signal. 2 (67), eg5. [DOI: 10.1126/scisignal.267eg5]
 |  Abstract »  |  Full Text »  |  PDF »

PERSPECTIVES
Cancer
The Pharmacology of mTOR Inhibition

David A. Guertin and David M. Sabatini (21 April 2009)
Sci. Signal. 2 (67), pe24. [DOI: 10.1126/scisignal.267pe24]
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PERSPECTIVES
Immunology
Immune Regulation by Rapamycin: Moving Beyond T Cells

Matthew R. Janes and David A. Fruman (21 April 2009)
Sci. Signal. 2 (67), pe25. [DOI: 10.1126/scisignal.267pe25]
 |  Abstract »  |  Full Text »  |  PDF »

PERSPECTIVES
Cancer
Akt Demoted in Glioblastoma

Peter K. Vogt and Jonathan R. Hart (21 April 2009)
Sci. Signal. 2 (67), pe26. [DOI: 10.1126/scisignal.267pe26]
 |  Abstract »  |  Full Text »  |  PDF »

PERSPECTIVES
Biochemistry
New Insights into mTOR Signaling: mTORC2 and Beyond

Dario R. Alessi, Laura R. Pearce, and Juan M. García-Martínez (21 April 2009)
Sci. Signal. 2 (67), pe27. [DOI: 10.1126/scisignal.267pe27]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Cell Biology
Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR

Chao-Yung Wang, Hyung-Hwan Kim, Yukio Hiroi, Naoki Sawada, Salvatore Salomone, Laura E. Benjamin, Kenneth Walsh, Michael A. Moskowitz, and James K. Liao (17 March 2009)
Sci. Signal. 2 (62), ra11. [DOI: 10.1126/scisignal.2000143]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cancer
Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis

Caterina Nardella, Arkaitz Carracedo, Andrea Alimonti, Robin M. Hobbs, John G. Clohessy, Zhenbang Chen, Ainara Egia, Alessandro Fornari, Michelangelo Fiorentino, Massimo Loda, Sara C. Kozma, George Thomas, Carlos Cordon-Cardo, and Pier Paolo Pandolfi (27 January 2009)
Sci. Signal. 2 (55), ra2. [DOI: 10.1126/scisignal.2000189]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
GTP Hydrolysis
Characterization of the Intrinsic and TSC2-GAP–Regulated GTPase Activity of Rheb by Real-Time NMR

Christopher B. Marshall, Jason Ho, Claudia Buerger, Michael J. Plevin, Guang-Yao Li, Zhihong Li, Mitsuhiko Ikura, and Vuk Stambolic (27 January 2009)
Sci. Signal. 2 (55), ra3. [DOI: 10.1126/scisignal.2000029]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cancer
EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma

Qi-Wen Fan, Christine Cheng, Zachary A. Knight, Daphne Haas-Kogan, David Stokoe, C. David James, Frank McCormick, Kevan M. Shokat, and William A. Weiss (27 January 2009)
Sci. Signal. 2 (55), ra4. [DOI: 10.1126/scisignal.2000014]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »