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Sci. Signal., 28 April 2009
Vol. 2, Issue 68, p. re2
[DOI: 10.1126/scisignal.268re2]

REVIEWS

Signaling by Gasotransmitters

Asif K. Mustafa1, Moataz M. Gadalla2, and Solomon H. Snyder1,2,3*

1 Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2 Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract: Nitric oxide is well established as a major signaling molecule. Evidence is accumulating that carbon monoxide and hydrogen sulfide also are physiologic mediators in the cardiovascular, immune, and nervous systems. This Review focuses on mechanisms whereby they signal by binding to metal centers in metalloproteins, such as in guanylyl cyclase, or modifying sulfhydryl groups in protein targets.

* Corresponding author. E-mail: ssnyder{at}jhmi.edu

Citation: A. K. Mustafa, M. M. Gadalla, S. H. Snyder, Signaling by Gasotransmitters. Sci. Signal. 2, re2 (2009).

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