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Sci. Signal., 23 June 2009
Vol. 2, Issue 76, p. pe38
[DOI: 10.1126/scisignal.276pe38]


Activation of T Cells: Releasing the Brakes by Proteolytic Elimination of Cbl-b

M. Lienhard Schmitz*

Institute of Biochemistry, Medical Faculty, Friedrichstrasse 24, Justus-Liebig-University Giessen, 35392 Giessen, Germany.

Abstract: Activation of T lymphocytes relies on the simultaneous delivery of signals from the T cell receptor and co-receptors such as CD28. The absence of co-receptor signaling leads to a state of unresponsiveness called anergy, which prevents T cells from reacting against self antigens. The biochemical program that ensures the induction of anergy uses several mechanisms, including the synthesis of ubiquitin E3 ligases such as Cbl-b (Casitas B-lineage lymphoma). Because these E3 ligases function as gatekeepers to prevent the undesired activation of T cells, full and productive induction of the T cell response requires the restriction of these negative regulators by mechanisms that we are beginning to understand.

* Corresponding author. E-mail, lienhard.schmitz{at}

Citation: M. L. Schmitz, Activation of T Cells: Releasing the Brakes by Proteolytic Elimination of Cbl-b. Sci. Signal. 2, pe38 (2009).

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Vav1-phospholipase C-{gamma}1 (Vav1-PLC-{gamma}1) Pathway Initiated by T Cell Antigen Receptor (TCR{gamma}{delta}) Activation Is Required to Overcome Inhibition by Ubiquitin Ligase Cbl-b during {gamma}{delta}T Cell Cytotoxicity.
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