Science Signaling Podcast: 30 June 2009

Ulrik B. Nielsen¹ and Annalisa M. VanHook²

¹ Merrimack Pharmaceuticals, One Kendall Square, Building 700, Cambridge, MA 02139, USA.
² Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This is a conversation with Ulrik Nielsen, author of a Research Article published in the 30 June 2009 issue of Science Signaling. He discusses the use of mathematical models to predict candidate drug targets in signaling pathways involved in cancer.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH ARTICLES
Systems Biology
Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor–PI3K Axis

Birgit Schoeberl, Emily A. Pace, Jonathan B. Fitzgerald, Brian D. Harms, Lihui Xu, Lin Nie, Bryan Linggi, Ashish Kalra, Violette Paragas, Raghida Bukhalid, Viara Grantcharova, Neeraj Kohli, Kip A. West, Magdalena Leszczyniecka, Michael J. Feldhaus, Arthur J. Kudla, and Ulrik B. Nielsen (30 June 2009)
Sci. Signal. 2 (77), ra31. [DOI: 10.1126/scisignal.2000352]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORIAL GUIDES
Computational Biology
Why We Need Quantitative Dynamic Models

Ravi Iyengar (31 March 2009)
Sci. Signal. 2 (64), eg3. [DOI: 10.1126/scisignal.264eg3]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Computational Biology
Dynamic Signaling in the Hog1 MAPK Pathway Relies on High Basal Signal Transduction

Javier Macia, Sergi Regot, Tom Peeters, Núria Conde, Ricard Solé, and Francesc Posas (24 March 2009)
Sci. Signal. 2 (63), ra13. [DOI: 10.1126/scisignal.2000056]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Computational Biology
Fault Diagnosis Engineering of Digital Circuits Can Identify Vulnerable Molecules in Complex Cellular Pathways

Ali Abdi, Mehdi Baradaran Tahoori, and Effat S. Emamian (21 October 2008)
Sci. Signal. 1 (42), ra10. [DOI: 10.1126/scisignal.2000008]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »  |  Preview PDF »

RESEARCH ARTICLES
Computational Biology
Linear Motif Atlas for Phosphorylation-Dependent Signaling

Martin Lee Miller, Lars Juhl Jensen, Francesca Diella, Claus Jørgensen, Michele Tinti, Lei Li, Marilyn Hsiung, Sirlester A. Parker, Jennifer Bordeaux, Thomas Sicheritz-Ponten, Marina Olhovsky, Adrian Pasculescu, Jes Alexander, Stefan Knapp, Nikolaj Blom, Peer Bork, Shawn Li, Gianni Cesareni, Tony Pawson, Benjamin E. Turk, Michael B. Yaffe, Søren Brunak, and Rune Linding (2 September 2008)
Sci. Signal. 1 (35), ra2. [DOI: 10.1126/scisignal.1159433]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

REVIEWS
Cell Biology
Sequestration and Segregation of Receptor Kinases in Epithelial Cells: Implications for ErbB2 Oncogenesis

Coralie A. Carothers Carraway and Kermit L. Carraway (10 April 2007)
Sci. STKE 2007 (381), re3. [DOI: 10.1126/stke.3812007re3]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »

Computational Biology
Rules for Modeling Signal-Transduction Systems

William S. Hlavacek, James R. Faeder, Michael L. Blinov, Richard G. Posner, Michael Hucka, and Walter Fontana (18 July 2006)
Sci. STKE 2006 (344), re6. [DOI: 10.1126/stke.3442006re6]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »